期刊
PHARMACOGNOSY RESEARCH
卷 7, 期 4, 页码 314-321出版社
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/0974-8490.167893
关键词
Alpha-amylase inhibitor; Brown algae; Sargassum glaucescens; Sterol
资金
- Tehran University of Medical Sciences and Health Services Grant [17619]
Background: Sargassum species (phaeophyceae) are economically important brown algae in southern parts of Iran. Sargassum is mainly harvested as a row material in alginate production industries and is a source of plant foods or plant bio-stimulants even a component of animal foods. Objective: In this study, Sargassum glaucescens, collected from the seashore of Chabahar, was employed for phytochemical and biological evaluations. Materials and Methods: For that purpose, the dried algae was extracted by methanol and subjected to different chromatographic separation methods. Results: Six sterols, fucosterol (1), 24(S)-hydroxy-24-vinylcholesterol (2), 24(R)-hydroxy-24-vinylcholesterol (3), stigmasterol (4), beta-sitosterol (5) and cholesterol (6) were identified by spectroscopic methods including H-1-NMR, C-13-NMR and mass spectroscopy. In vitro alpha-amylase inhibitory test was performed on the methanolic extract and the results revealed a potent inhibition (IC50 = 8.9 2.4 mg/mL) of the enzyme compared to acarbose as a positive control. Conclusion: Various biological activities and distribution of sterols in Sargassum genus have been critically reviewed here. The results concluded that these algae are a good candidate for further anti-diabetic investigations in animals and human.
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