期刊
TRENDS IN CANCER
卷 1, 期 2, 页码 93-109出版社
CELL PRESS
DOI: 10.1016/j.trecan.2015.08.010
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资金
- US National Institutes of Health Prostate Specialized Program of Research Excellence grant [P50 CA69568]
- Early Detection Research Network grant [UO1 CA111275]
- US National Institutes of Health [R01 CA132874]
- US Department of Defense [PC100171]
- Prostate Cancer Foundation
- Howard Hughes Medical Institute
- National Institutes of Health Ruth L. Kirschstein National Research Service Award [F30 CA180376]
- Howard Hughes Medical Institute Medical Research Fellows Program
- Prostate Cancer Foundation Young Investigator Award
While our understanding of the molecular mechanisms underlying cancer has significantly improved, most of our knowledge focuses on protein-coding genes that make up a fraction of the genome. Recent studies have uncovered thousands of long noncoding RNAs (lncRNAs) that populate the cancer genome. A subset of these molecules show striking cancer- and lineage-specific expression patterns, suggesting that they may be potential drivers of cancer biology and have utility as clinical biomarkers. We discuss emerging modalities of lncRNA biology and their interplay with cancer-associated concepts, including epigenetic regulation, DNA damage and cell cycle control, microRNA silencing, signal transduction pathways, and hormone-driven disease. In addition, we highlight the translational impact of lncRNAs, tools for their mechanistic investigation, and directions for future lncRNA research.
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