期刊
DERMATITIS
卷 29, 期 2, 页码 57-62出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/DER.0000000000000340
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Atopic dermatitis is a multifactorial disease. Epidermal barrier impairment often plays the initial role in the initiation of the disease. Immune dysregulation of the innate and adaptive immunity plays a central role in the pathogenesis of atopic dermatitis. Alteration of the epidermal microbiome-host interaction serves a catalytic role in propagating this immune response. The understanding of this disease pathogenesis is important in generating treatment options, especially those such as biologic agents that can target a specific immune pathway.
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