期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 45, 期 3-4, 页码 131-151出版社
KARGER
DOI: 10.1159/000486546
关键词
Acetylcholinesterase inhibitor; Memantine; Alzheimer disease; Vascular dementia; Systematic review; Meta-analysis
资金
- National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
- MRC [MC_PC_17214] Funding Source: UKRI
Background: Acetylcholinesterase inhibitors (AChEIs) and memantine are commonly used in the management of dementia. In routine clinical practice, dementia is often monitored via the Mini-Mental State Examination (MMSE). We conducted a systematic review and meta-analysis of the effects of these drugs on MMSE scores. Summary: Eighty trials were identified. Pooled effect estimates were in favour of both AChEIs and memantine at 6 months. Meta-regression indicated that dementia subtype was a moderator of AChEI treatment effect, with the effect of treatment versus control twice as high for patients with Parkinson disease dementia/dementia with Lewy bodies (2.11 MMSE points at 6 months) as for patients with Alzheimer disease/vascular dementia (0.91 MMSE points at 6 months). Key Messages: AChEIs demonstrate a modest effect versus control on MMSE scores which is moderated by dementia subtype. For memantine the effect is smaller. (C) 2018 S. Karger AG, Basel
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