期刊
EMERGING INFECTIOUS DISEASES
卷 21, 期 10, 页码 1784-1793出版社
CENTERS DISEASE CONTROL
DOI: 10.3201/eid2110.150623
关键词
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资金
- National Science and Technology Major Projects of China [2012ZX10004213-005]
- Science and Technology Planning Project of Guangdong Province, China [2013B021800029]
- Science and Technology Program of Guangzhou, China [2014Y2-00031]
- National Natural Science Foundation of China [81473034]
- Harvard Center for Communicable Disease Dynamics from the National Institute of General Medical Sciences [U54 GM088558]
- Area of Excellence Scheme of the Hong Kong University Grants Committee [AoE/M-12/06]
- Health and Medical Research Fund of the Food and Health Bureau, government of the Hong Kong Special Administrative Region [RRG-12]
- MedImmune Inc.
- Sanofi Pasteur
- Crucell
We assessed the effect of closing live poultry markets in China on influenza A(H7N9) virus detection and viability. Intensive sampling was carried out before, during, and after a 2-week citywide market closure; the markets were cleaned and disinfected at the beginning of the closure period. Swab samples were collected at different sites within the markets and tested for H7N9 by real-time reverse transcription PCR and culture. During the closure, H7N9 viral RNA detection and isolation rates in retail markets decreased by 79% (95% Cl 64%-88%) and 92% (95% Cl 58%-98%), respectively. However, viable H7N9 virus could be cultured from wastewater samples collected up to 2 days after the market closure began. Our findings indicates that poultry workers and the general population are constantly exposed to H7N9 virus at these markets and that market closure and disinfection rapidly reduces the amount of viable virus.
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