Effect of particle surface charge on drug uptake

In this paper, it aims to build the relationship of statically electric interaction between the surface charge of a particle drug and cellular uptake. The statically electric theory is applied to study the change of wetting between the drug particle and the cell, a factor that enhanced uptake of cells induced by particle's surface charge is introduced, then it is formulated according to Kelvin theory for dissolving of solid particle in liquid. It is found that the change of contact angle between the surface charged particle drug and the cell can be detected if the Zeta potential reaches to 6 mV in water like solution, an increase of about 11.1% for the uptake could be obtained for a polymer particle with molar mass M similar to 10 kg/mol, mass density p similar to 0.9 x 10(3) kg/m(3), radius r similar to 15 nm at temperature 300 K and Zeta potential 10 mV condition as compared with the same particle in water-like solution but without surface charge. The effect of particle surface charge on drug uptake could be interpreted by statically electric theory.