期刊
CYTOTHERAPY
卷 20, 期 3, 页码 314-321出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jcyt.2017.11.012
关键词
brain injury; mesenchymal stromal cells; platelet-rich plasma scaffolds; transplantation
类别
资金
- Mapfre Foundation
- Rafael del Pino Foundation
Background. Cell therapy using mesenchymal stromal cells (MSCs) offers new perspectives in the treatment of traumatic brain injury (TBI). The aim of the present study was to assess the impact of platelet-rich plasma scaffolds (PRPS) as support of MSCs in a delayed phase after severe TBI in rats. Methods. TBI was produced by weight-drop impact to the right cerebral hemisphere. Two months after TBI, four experimental groups were established; saline, PRPS, MSCs in saline, or MSCs in PRPS was transplanted into the area of brain lesion through a small hole. All groups were evaluated in the course of the following 12 months after therapy and the animals were then humanely killed. Results. Our results showed that a greater functional improvement was obtained after the administration of MSCs in PRPS compared with the other experimental groups. Discussion. PRPS enhanced the benefit of cell therapy with MSCs to treat chronic brain damage in rats that suffered a severe TBI. The present findings suggest that the use of intralesional MSCs supported in PRPS may be a strategy of tissue engineering for patients with established neurological severe dysfunction after a TBI.
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