期刊
ACTA VIROLOGICA
卷 59, 期 2, 页码 103-116出版社
AEPRESS SRO
DOI: 10.4149/av_2015_02_103
关键词
monoclonal antibody; conformational epitope; X-ray crystallography; NMR; display technologies; mass spectrometry
类别
资金
- Axon Neuroscience and Research grants [LPP-0038-09, VEGA 2/0177/15, 2/0163/13, APVV 0200-11]
Antibodies are broadly used in clinical and basic research. Many of monoclonal antibodies are successfully adopted for therapeutic and diagnostic targeting of viral pathogens. Efficacy of antiviral neutralizing or protective antibodies depends on their ability to recognize epitopes interfering with viral infection. However, viruses are able to incessantly change their antigenic determinants to escape surveillance of humoral immune system and therefore the successful antiviral therapies require continuous development. Characterization of interactions of antibodies with prevalently conformational viral epitopes is important for understanding antibody mode of action and can help to identify conserved regions that may be exploited in designing new vaccines and virus neutralizing antibodies. In this article, we are reviewing techniques in use for characterization of conformational epitopes of monoclonal antibodies with focus on viruses.
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