期刊
CURRENT PHARMACEUTICAL DESIGN
卷 23, 期 40, 页码 6206-6214出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612823666170913164738
关键词
Adsorptive-mediated transcytosis (AMT); blood-brain barrier (BBB); extracellular vesicles (EVs); endothelial cell; exosome; neurodegenerative disease; Parkinson's disease (PD); receptor-mediated transcytosis (RMT)
资金
- National Institutes of Health (NIH) [U01 NS091272, U01 NS082137, P30 ES007033, R01 ES019277]
- Micheal J. Fox Foundation
Recently, extracellular vesicles (EVs), like exosomes and microvesicles, have attracted attention as potent carriers of intercellular communication throughout the body, including the brain. They transmit biological signals from donor cells to recipient cells, and recent evidence suggests that they may even carry such signals to distant destinations through peripheral circulation. In the central nervous system (CNS), EVs contribute to maintaining normal neuronal function, as well as to the pathological development of neurodegenerative diseases. Although some evidence has suggested that EVs can cross the blood-brain barrier (BBB), moving from the peripheral circulation to the CNS, the mechanisms by which EVs facilitate communication between peripheral tissues and the CNS are not well understood. The BBB is a dynamic interface that regulates molecular trafficking between the peripheral circulation and the CNS. However, there is limited mechanistic understanding of how blood-borne EVs cross the BBB under physiological and pathological conditions. In this review, we focus on current knowledge of trafficking of EVs between the peripheral circulation and the brain. Moreover, we describe hypothetical transport routes by which EVs may cross the BBB based on previous reports. Further investigation is needed to understand the precise mechanisms by which EVs are transported across the BBB.
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