期刊
FORENSIC TOXICOLOGY
卷 34, 期 1, 页码 133-143出版社
SPRINGER
DOI: 10.1007/s11419-015-0297-2
关键词
N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-benzyl-1H-indazole-3-carboxamide (ADB-BINACA); N-(1-Amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indole-3-carboxamide (AB-FUBICA); N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indole-3-carboxamide (ADB-FUBICA); N-(1-Amino-3-methyl-1-oxobutan-2-yl)-1-benzyl-1H-indole-3-carboxamide (AB-BICA); Synthetic cannabinoid; New psychoactive substance
类别
资金
- Program of National Science & Technology Pillar [2011BAK04B06]
We identified four cannabimimetic indazole and indole derivatives in new illegal psychoactive substances seized from a clandestine laboratory in China. These four derivatives includedN-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-benzyl-1H-indazole-3-carboxamide (ADB-BINACA, 1), N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indole-3-carboxamide (AB-FUBICA, 2), N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indole-3-carboxamide (ADB-FUBICA, 3), and N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-benzyl-1H-indole-3-carboxamide (AB-BICA, 4). These compounds were identified by liquid chromatography-high-resolution mass spectrometry, gas chromatography-mass spectrometry, and nuclear magnetic resonance spectroscopy. No chemical or pharmacological data about compound 4 has appeared until now, making this the first report on this compound. Compounds 1, 2, and 3 have previously been reported to have a high affinity for cannabinoid CB1 and CB2 receptors, but this is the first report of their presence in illegal products.
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