期刊
CURRENT PHARMACEUTICAL DESIGN
卷 23, 期 44, 页码 6784-6794出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612823666171018114331
关键词
IAM chromatography; blood-brain barrier; skin permeability; oral bioavailability
资金
- Medical University of Lodz [503/3-016-03/503-31-001]
A review of applications of the Immobilized Artificial Membrane (IAM) chromatography in drug discovery is given. IAM chromatography is presented as a tool to predict the interactions of solutes with biomembranes, blood-brain barrier permeability, volume of distribution, oral and skin absorption of drugs and compared to other in vitro techniques used to study drug bioavailability (caco-2 cells, liposome partition). Unbound phosphatidylcholine based stationary phases are also discussed. Some new trends and ideas in the IAM chromatography are presented.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据