期刊
CURRENT ORGANIC CHEMISTRY
卷 22, 期 6, 页码 519-532出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272822666180123145819
关键词
Carbon-carbon bond; aldol reaction; compounds biologically active; green chemistry; knoevenagel condensation; cyano malononitrile-derivatives
资金
- CNPq
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
- Nucleo de Pesquisa em Ciencia e Tecnologia de BioRecursos (CITECBio) of the University of Sao Paulo [2012.1.25895.13]
- CNPq (Programa Ciencia sem Fronteiras - Pequisador Visitante Especial (PVE)) [400202/2014-0]
Knoevenagel condensation was discovered in the 20th century, and since then it has been present in a wide range of reactions in organic chemistry due to its potential for forming carbon-carbon bonds. This reaction is usually carried out between aldehydes or ketones and active methylene compounds in the presence of Lewis acids or basic catalysts. The great advantage of this reaction is that can be carried out in mild conditions, with easy handling and using solvents with low toxicity. In the last 15 years, this type of organic synthesis has been used for the formation of alpha,beta unsaturated carbonyl compounds according to the principles of Green Chemistry. The use of microwave radiation to perform Knoevenagel condensation reactions is today a reality due to their ability to reduce the reaction time from hours to minutes, absence of unwanted products and free-solvent reactions. In this article we will review and discuss a collection of these reactions under microwave radiation dividing it into two strands. The first presents the condensation of Knoevenagel between malononitrile and aldehydes and the second one, addresses the alternatives to use malononitrile-derivatives such as cyanoacetamides and cyanoacetates. The Knoevenagel adducts formed from aldehydes present excellent results in terms of reaction yield (above 90 %) in short reaction times (< 10 min). The authors left their contributions in order to corroborate with this complete analysis on the new trends of this subject with great potential on Green Chemistry.
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