期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 53, 期 -, 页码 88-99出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2018.06.004
关键词
-
资金
- National Institutes of Health [GM049245]
- Cancer Prevention and Research Institute of Texas [RR160029]
The generation, alteration, recognition, and erasure of epigenetic modifications of DNA are fundamental to controlling gene expression in mammals. These covalent DNA modifications include cytosine methylation by AdoMet-dependent methyltransferases and 5-methylcytosine oxidation by Fe(II)-dependent and alpha-ketoglutarate-dependent dioxygenases. Sequence-specific transcription factors are responsible for interpreting the modification status of specific regions of chromatin. This review focuses on recent developments in characterizing the functional and structural links between the modification status of two DNA bases: 5-methylcytosine and 5-methyluracil (thymine).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据