期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 50, 期 -, 页码 162-170出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2018.04.005
关键词
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资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2016R-1A6A3A-03009038]
- Canadian Institute for Health Research [CIHR MOP-123526, PJT-153279]
Protein protein interactions (PPIs) are essential to governing virtually all cellular processes. Of particular importance are the versatile motif-mediated interactions (MMIs), which are thus far underrepresented in available interaction data. This is largely due to technical difficulties inherent in the properties of MMIs, but due to the increasing recognition of the vital roles of MMIs in biology, several systematic approaches have recently been developed to detect novel MMIs. Consequently, rapidly growing numbers of motifs are being identified and pursued further for therapeutic applications. In this review, we discuss the current understanding on the diverse functions and disease-relevance of MMIs, the key methodologies for detection of MMIs, and the potential of MMIs for drug development.
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