期刊
CURRENT OPINION IN PSYCHIATRY
卷 31, 期 3, 页码 176-182出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/YCO.0000000000000419
关键词
circadian rhythms; insomnia; schizophrenia; sleep; sleep spindles
类别
资金
- Wellcome Trust [098461/Z/12/Z]
- National Institute for Health Research (NIHR) Oxford Biomedical Research Centre based at Oxford University Hospitals NHS Trust [A90305]
- Fulbright Commission
- Medical Research Council
- St. John's College
- NIHR
- Merck, Inc.
- National Institute of Health
- American Sleep Medicine Foundation
- Doris Duke Foundation
- NASA
- Oxford
Purpose of reviewThe review is designed to give an overview of the latest developments in research exploring the relationship between sleep and psychosis, with particular attention paid to the evidence for a causal relationship between the two.Recent findingsThe most interesting avenues currently in pursuit are focused upon sleep spindle deficits which may hallmark an endophenotype; explorations of the continuum of psychotic experiences, and experimental manipulations to explore the evidence for bidirectional causality; inflammatory markers, psychosis and sleep disturbances and finally, treatment approaches for sleep in psychosis and the subsequent impact on positive experiences.SummaryGlobally, large surveys and tightly controlled sleep deprivation or manipulation experiments provide good evidence for a cause-and-effect relationship between sleep and subclinical psychotic experiences. The evidence for cause-and-effect using a interventionist-causal model is more ambiguous; it would appear treating insomnia improves psychotic experiences in an insomnia cohort but not in a cohort with schizophrenia. This advocates the necessity for mechanism-driven research with dimensional approaches and in depth phenotyping of circadian clock-driven processes and sleep regulating functions. Such an approach would lead to greater insight into the dynamics of sleep changes in healthy and acute psychosis brain states.
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