期刊
FEMS MICROBIOLOGY LETTERS
卷 362, 期 17, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femsle/fnv141
关键词
genomics; functional genomics; microbiota; bifidobacteria; host-microbe interactions
类别
资金
- Science Foundation Ireland (SFI), through Irish Government's National Development Plan [SFI/12/RC/2273]
Bifidobacteria are colonizers of the human gut, where they are interacting with their host as well as with other members of the intestinal microbiota. Teichoic acids (TAs) have previously been shown to play an important role in modulating microbe-host interactions in the human gut. However, so far, there is a paucity of information regarding the presence of TAs in the cell envelope of bifidobacteria. In silico analyses targeting the chromosomes of all 48 (sub) species that currently represent the genus Bifidobacterium revealed the presence of genes responsible for TA biosynthesis, suggesting that bifidobacteria contain both wall TAs and lipoteichoic acids. Transcriptome analyses of the infant gut commensal Bifidobacterium bifidum PRL2010 highlighted that the transcription of the presumptive TA biosynthetic loci is modulated in response to environmental conditions reflecting those of the human gut. Furthermore, chemical characterization of TAs produced by PRL2010 indicates the presence of lipoteichoic acids.
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