期刊
CURRENT OPINION IN MICROBIOLOGY
卷 43, 期 -, 页码 1-8出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2017.10.005
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资金
- NIH National Institute of General Medical Sciences [GM103310]
- Simons Foundation [349247]
- Agency for Science, Technology and Research Singapore
The scope and complexity of cryogenic electron microscopy (cryoEM) data has greatly increased, and will continue to do so, due to recent and ongoing technical breakthroughs that have led to much improved resolutions for macromolecular structures solved using this method. This big data explosion includes single particle data as well as tomographic tilt series, both generally acquired as direct detector movies of similar to 10-100 frames per image or per tilt-series. We provide a brief survey of the developments leading to the current status, and describe existing cryoEM pipelines, with an emphasis on the scope of data acquisition, methods for automation, and use of cloud storage and computing.
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