期刊
CURRENT OPINION IN MICROBIOLOGY
卷 41, 期 -, 页码 15-20出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2017.11.006
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资金
- Biotechnology and Biological Sciences Research Council (BBSRC) Grant [BB/N002539/1, BB/L007959/1]
- Medical Research Council (MRC) Career Development Award [MR/M009505/1]
- Swiss National Science Foundation Postdoc Mobility Fellowship [P300PA_167703]
- Swiss National Science Foundation (SNF) [P300PA_167703] Funding Source: Swiss National Science Foundation (SNF)
- Biotechnology and Biological Sciences Research Council [BB/R00174X/1, BB/N002539/1, BB/L007959/1] Funding Source: researchfish
- Medical Research Council [MR/P028225/1, MR/M009505/1] Funding Source: researchfish
- BBSRC [BB/R00174X/1, BB/N002539/1, BB/L007959/1] Funding Source: UKRI
- MRC [MR/P028225/1, MR/M009505/1] Funding Source: UKRI
Pseudomonas aeruginosa acute and chronic infections are of great concern to human health, especially in hospital settings. It is currently assumed that P. aeruginosa has two antagonistic pathogenic strategies that parallel two different lifestyles; free-living cells are predominantly cytotoxic and induce an acute inflammatory reaction, while biofilm-forming communities cause refractory chronic infections. Recent findings suggest that the planktonic-to-sessile transition is a complex, reversible and overall dynamic differentiation process. Here, we examine how the Gac/Rsm regulatory cascade, a key player in this lifestyle switch, endows P. aeruginosa with both a permissive lifecycle in nature and flexible virulence strategy during infection.
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