期刊
CURRENT OPINION IN MICROBIOLOGY
卷 41, 期 -, 页码 29-35出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2017.11.010
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资金
- University of Zurich
- Swiss National Science Foundation (SNF) [31003A_153200]
- SNF Ambizione Fellowship [PZ00P3_161492]
- Swiss National Science Foundation (SNF) [PZ00P3_161492, 31003A_153200] Funding Source: Swiss National Science Foundation (SNF)
Legionella pneumophila is a water-borne opportunistic pathogen causing a life-threatening pneumonia called 'Legionnaires' disease'. The Legionella quorum sensing (Lqs) system produces and responds to the alpha-hydroxyketone signaling molecule 3-hydroxypentadecane-4-one (Legionella autoinducer-1, LAI-1). The Lqs system controls the switch between the replicative/non-virulent and the transmissive/virulent phase of L. pneumophila, and it is a major regulator of natural competence, motility and virulence of the pathogen. Yet, beyond gene regulation, LAI-1 also directly affects pathogen-host interactions, since the signaling molecule modulates the migration of eukaryotic cells. Genes encoding Lqs homologues are present in many environmental bacteria, suggesting that alpha-hydroxyketone signaling is widely used for inter-bacterial as well as inter-kingdom signaling. In this review we summarize recent advances on the characterization of the Lqs system and its role in L. pneumophila-host cell interactions.
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