期刊
CURRENT OPINION IN LIPIDOLOGY
卷 29, 期 4, 页码 279-284出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOL.0000000000000525
关键词
fluid-phase pinocytosis; intracellular lipids; multiply modified LDL
资金
- Russian Science Foundation [14-15-00112]
- Russian Science Foundation [17-15-00014] Funding Source: Russian Science Foundation
Purpose of reviewLipoprotein-induced intracellular lipid accumulation (foam cell formation) is a trigger of atherogenesis at the subendothelial arterial cell level. The purpose of this review is to describe the recent data related to the possible mechanisms of LDL-induced formation of lipid-laden foam cells and their role in the onset and development of atherosclerotic lesion.Recent findingsThe most interesting current studies are related to the factors affecting foam cell formation.SummaryThe phenomenon of lipid accumulation in cultured cells became the basis for creating a cellular test system that has already been successfully applied for development of drugs possessing direct antiatherosclerotic activity, and then the efficacy of these drugs was demonstrated in clinical studies. Moreover, this test system could be used for diagnostic assessing lipoproteins atherogenicity.
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