期刊
CURRENT OPINION IN IMMUNOLOGY
卷 54, 期 -, 页码 115-122出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2018.06.009
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类别
资金
- Swiss National Science Foundation [310030-172978]
- Hochspezialisierte Medizin Schwerpunkt Immunologic [HSM-2-Immunologic]
- Swiss National Science Foundation (SNF) [310030_172978] Funding Source: Swiss National Science Foundation (SNF)
Type 2 immune responses contribute to the resistance to helminths and toxins as well as several physiological processes. Although they usually do not participate in type 2 immune responses, neutrophils have been shown in mice to enhance the anti-helminth response, but they also contribute to increased target tissue damage. Increased pathology and morbidity is also observed in type 2 immune-mediated disorders, such as allergic asthma, when neutrophils become a predominant subset of the infiltrate. How neutrophil recruitment is regulated during type 2 immune responses is now starting to become clear, with recent data showing that signaling via the prototypic type 2 cytokine interleukin-4 receptor mediates direct and indirect inhibitory actions on neutrophils in mice and humans.
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