期刊
CURRENT OPINION IN IMMUNOLOGY
卷 50, 期 -, 页码 112-116出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2018.01.004
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资金
- Rainin foundation, NIH [U01 AI095542, DK103039]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U01AI095542] Funding Source: NIH RePORTER
The immune system of the intestinal tract has the challenging task of recognizing and eliminating intestinal pathogens while maintaining tolerance to dietary and commensal antigens; therefore, it must be able to sense environmental cues within the intestine and mount suitable responses dictated by their pathogenic or nonpathogenic nature. The aryl hydrocarbon receptor (AHR) was originally characterized as a chemical sensor of the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) [121]. More recently, AHR has emerged as a major chemical sensor expressed in many intestinal immune cells that enables them to distinguish nutritional and microbial cues and is, therefore, important for development, maintenance and function of the intestinal immune system. In this review, we will highlight recent advances in our knowledge of the role of AHR signaling in intestinal innate lymphoid cells (ILC), T cells and B cells.
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