期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 48, 期 -, 页码 82-88出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2017.11.001
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资金
- National Center for Advancing Translational Sciences (NCATS) [NIH RO1CA178509, NIH RO1CA207893, BCRF-16-143, ACS PF-16-095-01-RMC, T32 CA9161-41, NIH GM066704, 5T32 GM066704, UL1 TR00038]
- National Institutes of Health, the Howard Hughes Medical Institute
Deregulation of several translation initiation factors occurs in numerous types of cancers. Translation initiation factors are not merely ancillary players in cancer development and progression, but rather, they are key participants in cellular transformation and tumor development. In fact, the altered expression of translation initiation factors is involved in cancer cell survival, metastasis and tumor angiogenesis. Although the exact mechanisms remain to be fully characterized, translation initiation factors comprise novel targets for pharmacologic intervention. Here we review the most recently established roles of initiation factors in cancer development and progression, as well as unique methods used to study translational regulation.
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