期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 52, 期 -, 页码 29-35出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2018.05.004
关键词
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资金
- National Key Research and Development Program of China [2017YFA0103000, 2017YFA0104003]
- National Natural Science Foundation of China [31730059, 31521004]
- Guangdong Innovative and Entrepreneurial Research Team Program [2014ZT05S216]
- Science and Technology Planning Project of Guangdong Province, China [2014B020226001, 2016B030232001]
- Science and Technology Program of Guangzhou, China [201508020001]
- BeiHao Stem Cell and Regenerative Medicine Translational Research Institute
Cellular fate reprogramming holds great promise to generate functional cell types for replenishing new cells and restoring functional loss. Inspired by transcription factor-induced reprogramming, the field of cellular reprogramming has greatly advanced and developed into divergent streams of reprogramming approaches. Remarkably, increasing studies have shown the power and advantages of small molecule-based approaches for cellular fate reprogramming, which could overcome the limitations of conventional transgenic-based reprogramming. In this concise review, we discuss these findings and highlight the future potentiality with particular focus on this new trend of chemical reprogramming.
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