期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 46, 期 -, 页码 25-32出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2018.03.019
关键词
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资金
- Australian National University Futures Scheme
- Australian Research Council (ARC) Discovery Early Career Researcher Award (DECRA) [DE180100092]
Transition-metal catalysis has unlocked new paradigms for the late-stage modification and cyclization of peptides by harnessing the innate reactivity of proteinogenic amino acids. The field is rapidly evolving, with recent advances encompassing three fundamental areas - heteroatom couplings, decarboxylative cross-couplings, and C-H functionalizations - which have markedly extended the scope of conventional peptide modification and bioconjugation strategies. The advances outlined herein facilitate access to high-value peptide targets with promising applications in materials science and drug discovery.
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