期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 43, 期 -, 页码 113-118出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2017.12.010
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资金
- NIH [GM 79465]
- NSF
- Chemical Biology Training Grant from the NIH [T32 GM 066698]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM066698, R01GM079465] Funding Source: NIH RePORTER
Iron is an essential nutrient for life, and its capacity to cycle between different oxidation states is required for processes spanning oxygen transport and respiration to nucleotide synthesis and epigenetic regulation. However, this same redox ability also makes iron, if not regulated properly, a potentially dangerous toxin that can trigger oxidative stress and damage. New methods that enable monitoring of iron in living biological systems, particularly in labile Fe2+ forms, can help identify its contributions to physiology, aging, and disease. In this review, we summarize recent developments in activity-based sensing (ABS) probes for fluorescence Fe2+ detection.
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