期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 46, 期 -, 页码 56-62出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2018.04.002
关键词
-
资金
- Biotechnology and Biological Sciences Research Council [BB/P02114X/1]
- University of Manchester President's Award for Research Excellence
- National Natural Science Foundation of China [31471254, 31725002]
- Bureau of International Cooperation, Chinese Academy of Sciences [172644KYSB20170042]
- BBSRC [BB/M025640/1, BB/M005690/1, BB/P02114X/1, BB/M005690/2] Funding Source: UKRI
- EPSRC [EP/P017401/1] Funding Source: UKRI
Since the first synthetic gene was synthesized in 1970s, the efficiency and the capacity of made-to-order DNA sequence synthesis has increased by several orders of magnitude. Advances in DNA synthesis and assembly over the past years has resulted in a steep drop in price for custom made DNA. Similar effects were observed in DNA sequencing technologies which underpin DNA-reading projects. Today, synthetic DNA sequences with more than 10 000 bps and turnaround times of a few weeks are commercially available. This enables researchers to perform large-scale projects to write synthetic chromosomes and characterize their functionalities in vivo. Synthetic genomics opens up new paradigms to study the genome fundamentals and engineer novel biological functions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据