期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 43, 期 -, 页码 37-42出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2017.10.029
关键词
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资金
- National Institutes of Health [HL093446]
- Pelotonia Fellowship Program
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R21HL093446] Funding Source: NIH RePORTER
The development of metal complexes that promote degradation of nucleic acids has garnered significant interest as a result of their broad range of potential application. This review focuses on recent progress in the design and synthesis of metal complexes as artificial nucleases that promote either hydrolytic or oxidative cleavage of nucleic acids. Illustrative examples demonstrate the versatility of artificial nucleases for in vitro applications as molecular tools to address biochemical problems, as well as their potential use as therapeutic agents. We also address future challenges for improvement and avenues for further investigation.
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