期刊
CURRENT OPINION IN CELL BIOLOGY
卷 51, 期 -, 页码 42-49出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2017.10.008
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资金
- Medical Research Council [MC_U105192713]
- Cancer Research UK [C7379/A15291]
- MRC [MC_U105192713] Funding Source: UKRI
- Cancer Research UK [24639, 15291] Funding Source: researchfish
- Medical Research Council [MC_U105192713] Funding Source: researchfish
Three multiprotein complexes have key roles in transducing Wnt signals from the plasma membrane to the cell nucleus the beta-catenin destruction complex, or Axin degradasome, which targets the Wnt effector beta-catenin for proteasomal degradation in the absence of Wnt; the Wnt signalosome, assembled by polymerization of Dishevelled upon Wnt engaging its receptors, to inactivate the Axin degradasome, which allows beta-catenin to accumulate; and the Wnt enhanceosome which enables beta-catenin to gain access to target genes, to relieve their transcriptional repression by Groucho/TLE. This review focuses on recent advances that have highlighted mechanistic principles governing the assembly and function of these complexes.
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