期刊
CURRENT OPINION IN CELL BIOLOGY
卷 52, 期 -, 页码 105-111出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2018.02.013
关键词
-
类别
资金
- DFG [GR475/22-2, SFB1036]
- DKFZ-MOST grant
- Baden-Wurttemberg Stiftung
The nucleolus is the largest nuclear sub-compartment in which the early steps of ribosome biogenesis take place. It also plays an essential role in the assembly and function of non-ribosomal ribonucleoprotein (RNP) complexes, controls cell cycle progression and senses environmental stress. The spatial organization and dynamics of nucleolar proteins and RNA is regulated at different structural levels, which finally determine nucleolar architecture. The intimate link between nucleolar structure and function is reflected by transcription-dependent changes in nucleolus-associated chromatin, overall morphological alterations in response to external cues, and the liquid droplet-like behavior of nucleolar compartments. Here we provide a concise overview of the latest studies which integrate novel trends in nucleolar architecture research into the context of cell biology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据