期刊
CURRENT OPINION IN CELL BIOLOGY
卷 54, 期 -, 页码 30-36出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2018.03.001
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资金
- Abney Foundation Scholarship Award
- American Cancer Society Institutional Research Grant, Hollings Cancer Center, Medical University of South Carolina [IRG-16-185-17]
- College of Medicine Digestive Diseases Pilot & Feasibility Studies Award, Medical University of South Carolina
- Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health [P20GM103444]
- NIH [R01 NS101721, P50 CA116201]
- Mayo Clinic Center for Biomedical Discovery award
The adherens junction has been historically considered an essential structural component of epithelial tissues. Although primarily discussed as targets of signaling pathways responsible for cell fate and tissue remodeling, they have also emerged as critical signaling regulators in developmental processes or in disease progression. The recent discovery of a functional localized RNA interference (RNAi) machinery at epithelial adherens junctions revealed a new layer of signaling regulation that is directly associated with the structure itself. This and other findings also indicate that our view of the subcellular localization of RNAi requires revisiting. A number of questions emerge regarding the physiological role and the modes of regulation of the junctional RNAi machinery, pointing towards new directions of investigation.
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