期刊
CURRENT OPINION IN CARDIOLOGY
卷 33, 期 3, 页码 290-297出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HCO.0000000000000510
关键词
cardiovascular disease; exosomes; extracellular vesicles; microparticles; microvesicles
资金
- National Institutes of Health (NIH) [R01HL 114805, R01HL 136431]
- Harvard Catalyst Big Ideas, Small Features: Advanced Microscopic and Nanoscale Technologies Pilot Award
- American Heart Association [17SDG633670259]
Purpose of reviewExtracellular vesicles have emerged as one of the most important means through which cells interact with each other and the extracellular environment, but extracellular vesicle research remains challenging due to their small size, limited amount of material required for traditional molecular biology assays and inconsistency in the methods of their isolation. The advent of new technologies and standards in the field, however, have led to increased mechanistic insight into extracellular vesicle function. Herein, the latest studies on the role of extracellular vesicles in cardiovascular physiology and disease are discussed.Recent findingsExtracellular vesicles help control cardiovascular homeostasis and remodelling by mediating communication between cells and directing alterations in the extracellular matrix to respond to changes in the environment. The message carried from the parent cell to extracellular space can be intended for both local (within the same tissue) and distal (downstream of blood flow) targets. Pathological cargo loaded within extracellular vesicles could further result in various diseases. On the contrary, new studies indicate that injection of extracellular vesicles obtained from cultured cells into diseased tissues can promote restoration of normal tissue function.SummaryExtracellular vesicles are an integral part of cell and tissue function, and harnessing the properties inherent to extracellular vesicles may provide a therapeutic strategy to promote tissue regeneration.
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