期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 51, 期 -, 页码 109-115出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2017.12.007
关键词
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资金
- NIH [GM116864]
- CONACyT/Fundacion Mexico en Harvard [404476]
- Harvard Graduate Merit Fellowship
Non-genetic heterogeneity fluctuates over diverse timescales, ranging from hours to months. In specific cases, such variability can profoundly impact the response of cell populations to therapy, in both antibiotic treatments in bacteria and chemotherapy in cancer. It is thus critical to understand the way phenotypes fluctuate in cell populations and the molecular sources of phenotypic diversity. Technical and analytical breakthroughs in the study of single cells have leveraged cellular heterogeneity to gain phenomenological and mechanistic insights of the phenotypic transitions that occur within isogenic cell populations over time. Such an understanding moves forward our ability to design therapeutic strategies with the explicit goal of preventing and controlling the selective expansion and stabilization of drug-tolerant phenotypic states.
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