期刊
CURRENT MEDICINAL CHEMISTRY
卷 25, 期 25, 页码 2876-2893出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867324666170223154145
关键词
Graphene quantum dots; photoluminescence; cytotoxicity; bioimaging; fluorescent graphene quantum
资金
- National Natural Science Foundation of China (NSFC) [51573013]
- Deutsche Forschungsgemeinschaft (DFG) [WE 5837/1-1]
Fluorescent graphene quantum dots (GQDs) have attracted increasing interest in cancer bioimaging due to their stable photoluminescence (PL), high stability, low cytotoxicity, and good biocompatibility. In this review, we present the synthesis and chemical modification of GQDs firstly, and then introduce their unique physical, chemical, and biological properties like the absorption, PL, and cytotoxicity of GQDs. Finally and most importantly, the recent applications of GQDs in cancer bioimaging are demonstrated in detail, in which we focus on the biofunctionalization of GQDs for specific cancer cell imaging and real-time molecular imaging in live cells. We expect this work would provide valuable guides on the synthesis and modification of GQDs with adjustable properties for various biomedical applications in the future.
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