4.6 Review

Pigments from Filamentous Ascomycetes for Combination Therapy

期刊

CURRENT MEDICINAL CHEMISTRY
卷 26, 期 20, 页码 3812-3834

出版社

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867325666180330091933

关键词

Filamentous ascomycetes; Neurospora and Monascus; microbial pigments; filamentous fungi; HMG-CoA reductase; oncological diseases; hyperlipidaemia

资金

  1. Ministry of Education, Youth and Sports of the Czech Republic within the National Sustainability Program II [LQ1604]
  2. project BIOCEV'' [CZ.1.05/1.1.00/02.0109]
  3. Technology Agency of the Czech Republic [TE01020028, TH02010345]
  4. Charles University in Prague [UNCE 204011/2012, PRVOUK P24/LF1/3]
  5. National Programme of Sustainability I - NPU I [MSMT-43760/2015]
  6. Ministry of Education, Youth and Sports of the Czech Republic [LM201564]
  7. Ministry of Industry and Trade [FV20572]
  8. Operational Programme Prague-Competitiveness [CZ.2.16/3.1.00/21537]

向作者/读者索取更多资源

Filamentous ascomycetes (Neurospora and Monascus) have been studied for a long time because of their production of secondary metabolites such as microbial pigments. The ascomycetes represent an interesting group of compounds with high potential for medicinal applications. Many recent studies have shown their efficacy in the treatment of serious pathological states such as oncological diseases, neurodegenerative diseases and hyperlipidaemia. Nevertheless, the clinical usability of ascomycetes is still limited. However, this problem can be solved by the use of these compounds with combinations of other therapeutic agents. This strategy can suppress their side effects and improve their therapeutic efficacy. Moreover, their co-application can significantly enhance conventional therapies that are used. This review summarizes and discusses the general principles of this approach, introduced and supported by numerous examples. In addition, the prediction of the future potential application of this methodology is included.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据