期刊
CURRENT MEDICINAL CHEMISTRY
卷 26, 期 9, 页码 1512-1524出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867325666180320121137
关键词
Atherosclerosis; biomarker; desialylation; dysfunctional high-density lipoprotein; effector; modified low-density lipoprotein; multiple modification
资金
- Russian Science Foundation [14-15-00112]
Atherosclerotic diseases are the leading cause of mortality in industrialized countries. Correspondingly, studying the pathogenesis of atherosclerosis and developing new methods for its diagnostic and treatment remain in the focus of current medicine and health care. This review aims to discuss the mechanistic role of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) in atherogenesis. In particular, the generally accepted hypothesis about the key role of oxidized LDL in atherogenesis is questioned, and an alternative concept of multiple modification of LDL is presented. The fundamental question discussed in this review is whether LDL and HDL are effectors or biomarkers, or both. This is important for understanding whether lipoproteins are a therapeutic target or just diagnostic indicators.
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