期刊
CURRENT GENOMICS
卷 19, 期 3, 页码 227-239出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389202918666170717145716
关键词
Systems biology; Genome theory; System inheritance; Parts inheritance; Karyotype coding; Fuzzy inheritance; Genome re-organization; Genome chaos; Heterogeneity
资金
- WSU Office of the Vice President for Research Bridge Funding Grant
Background: The postgenomic era is featured by massive data collection and analyses from various large scale-omics studies. Despite the promising capability of systems biology and bioin-formatics to handle large data sets, data interpretation, especially the translation of-omics data into clinical implications, has been challenging. Discussion: In this perspective, some important conceptual and technological limitations of current systems biology are discussed in the context of the ultimate importance of the genome beyond the collection of all genes. Following a brief summary of the contributions of molecular cytogenetics/cytogenomics in the pre- and post-genomic eras, new challenges for postgenomic research are discussed. Such discussion leads to a call to search for a new conceptual framework and holistic methodologies. Conclusion: Throughout this synthesis, the genome theory of somatic cell evolution is highlighted in contrast to gene theory, which ignores the karyotype-mediated higher level of genetic information. Since system inheritance is defined by the genome context (gene content and genomic topology) while parts inheritance is defined by genes/epigenes, molecular cytogenetics and cytogenomics (which directly study genome structure, function, alteration and evolution) will play important roles in this postgenomic era.
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