期刊
CURRENT GENETICS
卷 64, 期 6, 页码 1205-1213出版社
SPRINGER
DOI: 10.1007/s00294-018-0842-8
关键词
Gene regulation; TOR; HMG-box; Ribosome; Hmo1; Ixr1; UBF1; HMGB1; Cell proliferation; Cancer
资金
- ISCIII-General Subdirection of Assesment and Promotion of the Research-European Regional Development Fund (FEDER) A way of making Europe [PI14/01031]
- Xunta de Galicia (Consolidacion Grupos Referencia Competitiva) [ED431C 2016-012]
- Xunta de Galicia-2013 (Spain) - FEDER
The number of ribosomes and their activity need to be highly regulated because their function is crucial for the cell. Ribosome biogenesis is necessary for cell growth and proliferation in accordance with nutrient availability and other external and intracellular signals. High-mobility group B (HMGB) proteins are conserved from yeasts to human and are decisive in cellular fate. These proteins play critical functions, from the maintenance of chromatin structure, DNA repair, or transcriptional regulation, to facilitation of ribosome biogenesis. They are also involved in cancer and other pathologies. In this review, we summarize evidence of how HMGB proteins contribute to ribosome-biogenesis control, with special emphasis on a common nexus to the target of rapamycin (TOR) pathway, a signaling cascade essential for cell growth and proliferation from yeast to human. Perspectives in this field are also discussed.
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