期刊
CURRENT CANCER DRUG TARGETS
卷 19, 期 2, 页码 109-119出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568009618666180530092825
关键词
Cancer; senescence; small molecule drugs; DNA damage responses; senescence-related signaling pathways; SASP
类别
资金
- National Natural Science Foundation [31471294, 31771521, 81672582]
- Natural Science Foundation of Jiangsu Province for Distinguished Young Scholars [BK20160013]
- Natural Science Foundation of Jiangsu Province [BE2016718]
- Six Talent Peak Project from Government of Jiangsu Province [2015-SWYY-019, 2016-SWYY-011]
- Top Talent of Innovative Research Team of Jiangsu Province
- Jiangsu Recruitment Program of Leading Creative and Entrepreneurial Talents
- Start-up Scientific Research Fund for the Returned Oversea Scholars from Chinese Ministry of Education
- Senior Talent Start-up Funds of Jiangsu University [14JDG050, 14JDG011]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Recently, the chemotherapeutic drug-induced cellular senescence has been considered a promising anti-cancer approach. The drug-induced senescence, which shows both similar and different hallmarks from replicative and oncogene-induced senescence, was regarded as a key determinant of tumor response to chemotherapy in vitro and in vivo. To date, an amount of effective chemotherapeutic drugs that can evoke senescence in cancer cells have been reported. The targets of these drugs differ substantially, including senescence signaling pathways, DNA replication process, DNA damage pathways, epigenetic modifications, microtubule polymerization, senescence-associated secretory phenotype (SASP), and so on. By summarizing senescence-inducing small molecule drugs together with their specific traits and corresponding mechanisms, this review is devoted to inform scientists to develop novel therapeutic strategies against cancer through inducing senescence.
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