期刊
CURRENT BIOLOGY
卷 28, 期 9, 页码 1333-+出版社
CELL PRESS
DOI: 10.1016/j.cub.2018.03.024
关键词
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资金
- Pfeiffer Foundation
- NIH NINDS [U01NS098961]
- NSF CAREER Award [BCS-1554105]
- McKnight Endowment Fund for Neuroscience
The encoding of information into long-term declarative memory is facilitated by dopamine. This process depends on hippocampal novelty signals, but it remains unknown how midbrain dopaminergic neurons are modulated by declarative-memory-based information. We recorded individual substantia nigra (SN) neurons and cortical field potentials in human patients performing a recognition memory task. We found that 25% of SN neurons were modulated by stimulus novelty. Extracellular waveform shape and anatomical location indicated that these memory-selective neurons were putatively dopaminergic. The responses of memory-selective neurons appeared 527 ms after stimulus onset, changed after a single trial, and were indicative of recognition accuracy. SN neurons phase locked to frontal cortical theta-frequency oscillations, and the extent of this coordination predicted successful memory formation. These data reveal that dopaminergic neurons in the human SN are modulated by memory signals and demonstrate a progression of information flow in the hippo-campal-basal ganglia-frontal cortex loop for memory encoding.
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