期刊
CURRENT BIOLOGY
卷 28, 期 7, 页码 1066-+出版社
CELL PRESS
DOI: 10.1016/j.cub.2018.02.044
关键词
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资金
- German Research Foundation (DFG) within the Graduate School [GRK-2174, NE465/19-1, NE465/27-1]
- German Research Foundation (DFG) within the Collaborative Research Center (SFB) [1134, 1158, DFG-ANR GR 3619/7-1, DFG-SNF GR 3619/8-1]
- Chica and Heinz Schaller Research Foundation and Human Frontiers Science Program [RGP0019/2015]
- Bayerische Forschungsstiftung grant [DOK-157-13]
- Federal Ministry of Education and Research (BMBF)
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Grants-in-Aid for Scientific Research [16K15698] Funding Source: KAKEN
Oxytocin (OXT)-mediated behavioral responses to social and stressful cues have extensively been studied in male rodents. Here, we investigated the capacity of brain OXT receptor (OXTR) signaling in the lateral septum (LS) to prevent social fear expression in female mice using the social-fear-conditioning paradigm. Utilizing the activated OXT system during lactation, we show that lactating mice did not express fear 24 hr after social fear conditioning. Supporting the role of OXTR signaling in the LS in attenuation of social fear, synthetic OXT infusion or overexpression of OXTR in the LS diminished social fear expression, whereas constitutive OXTR knockout severely impaired social fear extinction in virgin mice. Subsequently, both pharmacological blockade of local OXTRs in the LS and chemogenetic silencing of supraoptic nucleus OXTergic afferents to the LS increased social fear expression in lactating mice. Hence, LS-projecting OXT neurons suppress social fear in female mice.
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