期刊
CURRENT BIOLOGY
卷 28, 期 6, 页码 836-+出版社
CELL PRESS
DOI: 10.1016/j.cub.2018.01.081
关键词
-
资金
- German Israeli Foundation [I-1326-421.13]
Incentives drive goal-directed behavior; however, how they impact the formation and stabilization of goal-relevant hippocampal maps remains unknown. Since dopamine is involved in reward processing, affects hippocampal-dependent behavior, and modulates hippocampal plasticity, we hypothesized that local dopaminergic transmission in the hippocampus serves to mold the formation and updating of hippocampal cognitive maps to adaptively represent reward-predicting space of sensory inputs. We recorded CA1 place cells of rats throughout training on a spatial extra-dimensional set-shift task. After learning to rely on one of two orthogonal sets of cues, we introduced a rule shift and infused locally the D1/5 receptor (D1/5R) antagonist SCH23390. Successful learning was accompanied by place cell reorientation to represent rule-relevant spatial dimension. SCH23390 infusion prevented this re-mapping and, consequently, impaired learning, causing perseveration. These findings suggest that dopaminergic innervation provides reward information to the hippocampus and is critical for the stabilization of goal-related hippocampal representation, contributing to successful goal-directed behavior.
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