期刊
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
卷 11, 期 4, 页码 352-364出版社
WILEY
DOI: 10.1111/cts.12551
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资金
- Robert Bosch Stiftung, Stuttgart, Germany
- Federal Ministry for Education and Research (BMBF, Berlin, Germany) [FKZ 031L0037]
- Horizon 2020-PHC-2015 grant [U-PGx 668353]
- ICEPHA Graduate School Tuebingen-Stuttgart
- Deutsche Krebshilfe [FKZ 70112564]
The solute carrier (SLC) SLC16 gene family comprises 14 members and encodes for monocarboxylate transporters (MCTs), which mediate the absorption and distribution of monocarboxylic compounds across plasma membranes. As the knowledge about their physiological function, activity, and regulation increases, their involvement and contribution to cancer and other diseases become increasingly evident. Moreover, promising opportunities for therapeutic interventions by directly targeting their endogenous functions or by exploiting their ability to deliver drugs to specific organ sites emerge.
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