期刊
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
卷 129, 期 -, 页码 13-26出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2018.06.012
关键词
Senescence; Senescence-associated secretion phenotype; Radiosensitivity; Fibrotic tissue
资金
- Ministry of Education and Training (MOET, Vietnam)
- Association for Research and Training in Oncology-Radiotherapy (AREFOR)
Ionizing radiation-exposure induces a variety of cellular reactions, such as senescence and apoptosis. Senescence is a permanent arrest state of the cell division, which can be beneficial or detrimental for normal tissue via an inflammatory response and senescence-associated secretion phenotype. Damage to healthy cells and their microenvironment is considered as an important source of early and late complications with an increased risk of morbidity in patients after radiotherapy (RT). In addition, the benefit/risk ratio may depend on the radiation technique/dose used for cancer eradication and the irradiated volume of healthy tissues. For radiation-induced fibrosis risk, the knowledge of mechanisms and potential prevention has become a crucial point to determining radiation parameters and patients' intrinsic radiosensitivity. This review summarizes our understanding of ionizing radiation-induced senescent cell in fibrogenesis. This mechanism may provide new insights for therapeutic modalities for better risk/benefit ratios after RT in the new era of personalized treatments.
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