期刊
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
卷 123, 期 -, 页码 74-82出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2018.01.008
关键词
BRCA1; epithelial to mesenchymal transition; Drug resistance; Breast cancer; Metastasis
资金
- Rajiv Gandhi Centre for Biotechnology, Kerala State Council for Science Technology and Environment [016/SRSHS/2011/CSTE]
- Board of Research in Nuclear Sciences [2009/37/5/BRNS/1620, 37(1)/14/16/2014]
- Indian Council for Medical Research [53/20/2012-BMS]
- University Grants Commission
- Indian Council for Medical Research
Reports till its discovery has proven multiple facets of Breast Cancer type 1 susceptibility gene (BRCA1) from nucleus to cytoplasm; from DNA repair to drug resistance; from Homologous Recombination (FIR) to Ubiquitination; from breast to brain; from cancer to HIV and many of the roles are still unexplored. One of the recent attractions of BRCA1 is its role in regulating breast cancer metastasis though the exact mechanism is poorly understood. In this review, we will discuss the molecular interactions between BRCA1 and the key molecules of Epithelial to Mesenchymal Transition (EMT) associated with metastasis, its associated drug resistance and the possible treatment strategy for BRCA1 mutated breast cancer.
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