期刊
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
卷 55, 期 2, 页码 102-114出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10408363.2017.1422692
关键词
Hodgkin's lymphoma; pathology diagnosis; HIV and EBV infections
资金
- Romanian Research Ministry [PN-II-RU-TE-2014-4-1783, CNFIS-FDI-2017-1350]
- International Collaboration Grant [57 BM/2016]
Hodgkin's lymphoma (HL) constitutes a clonal expansion of what appears to be malignant B cells. Viruses are involved in its pathogenesis, such as the Epstein-Barr virus (EBV) and human immunodeficiency virus (HIV). Since these viral infections have been shown to play key roles in the pathogenesis of HL, countries with a prevalence of HIV and EBV represent interesting population targets to study the pathogenesis of HL, linking the evolution of the disease with viral infections. Usually, patients present with late stage disease often involving the bone marrow at the time of diagnosis. The present paper discusses the role of viral infection in African countries, as HL is considered to be a malignant disease characterized by an inflammatory reaction to an aberrant B cell clone that is well known as the Reed-Sternberg cell (HRS).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据