期刊
CRITICAL CARE MEDICINE
卷 46, 期 2, 页码 216-222出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CCM.0000000000002830
关键词
acute kidney injury; intrarenal pressure; ischemia reperfusion; renal decapsulation; renal tissue oxygen pressure
资金
- Fondo Nacional de Desarrollo Cientifico y Tecnologico [1160631]
- Proyecto en Ciencias Biomedicas y Clinicas Universidad Andres Bello [DI-749-15/CB]
- Sociedad Chilena de Pediatria Grant [2012001]
Objectives: Acute kidney injury is a serious complication with unacceptably high mortality that lacks of specific curative treatment. Therapies focusing on the hydraulic behavior have shown promising results in preventing structural and functional renal impairment, but the underlying mechanisms remain understudied. Our goal is to assess the effects of renal decapsulation on regional hemodynamics, oxygenation, and perfusion in an ischemic acute kidney injury experimental model. Methods: In piglets, intra renal pressure, renal tissue oxygen pressure, and dysoxia markers were measured in an ischemia-reperfusion group with intact kidney, an ischemia-reperfusion group where the kidney capsule was removed, and in a sham group. Results: Decapsulated kidneys displayed an effective reduction of intra renal pressure, an increment of renal tissue oxygen pressure, and a better performance in the regional delivery, consumption, and extraction of oxygen after reperfusion, resulting in a marked attenuation of acute kidney injury progression due to reduced structural damage and improved renal function. Conclusions: Our results strongly suggest that renal decapsulation prevents the onset of an intrinsic renal compartment syndrome after ischemic acute kidney injury.
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