期刊
CRITICAL CARE CLINICS
卷 34, 期 1, 页码 63-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccc.2017.08.003
关键词
Sepsis; Organ dysfunction; Microcirculation; Mitochondria; Metabolism; Inflammation
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [K08GM117310] Funding Source: NIH RePORTER
Sepsis-associated organ dysfunction involves multiple responses to inflammation, including endothelial and microvascular dysfunction, immune and autonomic dysregulation, and cellular metabolic reprogramming. The effect of targeting these mechanistic pathways on short- and long-term outcomes depends highly on the timing of therapeutic intervention. Furthermore, there is a need to understand the adaptive or maladaptive character of these mechanisms, to discover phase-specific biomarkers to guide therapy, and to conceptualize these mechanisms in terms of resistance and tolerance.
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