期刊
CORTEX
卷 107, 期 -, 页码 37-49出版社
ELSEVIER MASSON, CORPORATION OFFICE
DOI: 10.1016/j.cortex.2017.12.020
关键词
Cognitive models; Neuropsychology; Neuroimaging; Degeneracy; Ontologies
资金
- Wellcome [097720/Z/11/Z, 205103/Z/16/Z, 203147/Z/16/Z]
This paper provides a historical and future perspective on how neuropsychology and neuroimaging can be used to develop cognitive models of human brain functions. Section 1 focuses on the emergence of cognitive modelling from neuropsychology, why lesion location was considered to be unimportant and the challenges faced when mapping symptoms to impaired cognitive processes. Section 2 describes how established cognitive models based on behavioural data alone cannot explain the complex patterns of distributed brain activity that are observed in functional neuroimaging studies. This has led to proposals for new cognitive processes, new cognitive strategies and new functional ontologies for cognition. Section 3 considers how the integration of data from lesion, behavioural and functional neuroimaging studies of large cohorts of brain damaged patients can be used to determine whether inter-patient variability in behaviour is due to differences in the premorbid function of each brain region, lesion site or cognitive strategy. This combination of neuroimaging and neuropsychology is providing a deeper understanding of how cognitive functions can be lost and re-learnt after brain damage - an understanding that will transform our ability to generate and validate cognitive models that are both physiologically plausible and clinically useful. (C) 2017 Published by Elsevier Ltd.
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