期刊
COORDINATION CHEMISTRY REVIEWS
卷 366, 期 -, 页码 29-68出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2018.03.021
关键词
Fluorescence probes; GSH probes; Colorimetric chemosensors; Biothiol probes; Glutathione probe; Bioimaging
资金
- National Creative Research Initiative program [2012R1A3A2048814]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2017R1A6A3A04004954]
- Natural Science Foundation of China (NSFC) [21662037, 21762045]
- National Natural Science Foundation of China [21676113]
Glutathione (GSH) plays a key role in many cellular functions. Abnormal levels of GSH is considered to be sign of many diseases. As a result, various fluorescent imaging probes and/or chemosensors for GSH have been developed. Compared to other analytical methods, fluorescence has unique merits, such as excellent detection limits and sensitivity for use in imaging cells, tissues and small animals. However, colorimetric probes undergo distinct color changes, which in most cases can be detected by using the naked eye. This review of studies aimed at the development of GSH probes is presented in a format that is organized by structural features and chemical reactions of the probes. The topics include probes that are based on nanoparticles or nanocomposites, metal ion displacement and coordination and chemical reactions. The reaction based probes are further classified into probes that undergo cleavage of sulphonamide, sulfonate ester and related functional groups, Se-N bond cleavage, aryl substitution reactions, disulfide bond cleavage followed by cyclization, Michael additions, and other processes. (C) 2018 Elsevier B.V. All rights reserved.
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